KHẢO SÁT HOẠT TÍNH CHỐNG OXY HÓA CỦA NHŨ TƯƠNG NANO DYHYDROQUERCETIN

Tóm tắt

Dihydroquercetin (DHQ), also known as taxifolin, is a flavonoid and commonly found in many plants.
DHQ has been documented to have powerful antioxidant activity and many beneficial properties for
human health. However, its low solubility and bioavailability are major obstacles to biomedical
applications. In the present study, a DHQ nanoemulsion formulation was prepared by self
nanoemulsifying drug delivery system (SNEDDS) technique to overcome these disadvantages. The
obtained nanoemulsion system was also evaluated for its microscopic properties, and in vitro
antioxidant activity against artificial radical ABTS*
(2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic
acid) diammonium salt), protect cells. Measurement results showed that the DHQ nanoemulsion was
successfully synthesized with typical mean droplet sizes from 9 to 11 nm. The in vitro experiments on
antioxidant activities against ABTS radical indicated that both DHQ unencapsulated form and its
nanoemulsion effectively inhibit the development of ABTS*
free radical, however, DHQ nanoemulsion
inhibits better than the control Trolox with the IC50 values (µg/ml) of DHQ unencapsulated form, its
nanoemulsion and Trolox are respectively 474,2; 238,5; 331. The results of this study provide useful
information on the potential use of DHQ nanoemulsion as a promising agent in the tumor treatment
caused by free radicals and the development of a drug for the beings’aims.