XÁC ĐỊNH ĐỒNG THỜI HYDROCHLOROTHIAZIDE VÀ LOSARTAN POTASSIUM TRONG DƯỢC PHẨMBẰNG PHƯƠNG PHÁP QUANG PHỔHẤP THỤPHÂN TỬ UV-VIS KẾT HỢP CHEMOMETRICS

  • Trần Thúc Bình
  • Nguyễn văn Hợp
  • Hồ Xuân Anh Vũ
  • Trần Thị Ái Mỹ
  • Nguyễn Thị Quỳnh Trang

Tóm tắt

In this paper, Hydrochlorothiazide (HCT) and Losartan potassium (LSP) in tablet were simultaneously
determined by UV-Vis spectroscopy and chemometrics without separation. The spectra of standard and
sample solutions were measured in the wavelengths from 220 nm to 300 nm at 1.0 nm intervals.
Concentrations of HCT and LSP in sample solutions were computed by Classical Least Squares method
(CLS). Method validation was proved via recovery and repeatability of the results when analyzing HCT
and LSP in the sample of Splozarsin Plus tablet and compering the mean results of their contents in the
sample with that by HPLC method. The built process for analyzing tablet sample containing HCT and
LSP was not only simple to implement but also reduced the cost of analysis compared to the standard
method of high-performance liquid chromatography (HPLC).

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2023-03-07