HOẠT TÍNH KHÁNG OXY HÓA VÀ HIỆU QUẢ GIẢM ĐƯỜNG HUYẾT CỦA TRÀ VỎ BƯỞI NĂM ROI (Citrus grandis L.)

Tóm tắt

Pomelo peel contains a lot of important bioactive compounds having benefits for human health. This
pomelo peel (Citrus grandis L.) products have important health benefits, so pomelo peel tea has been
produced in order to enhance this great value. In-vitro and in-vivo studies on Nam Roi pomelo peel tea
extract combined with identified acute toxicity in white male mice at a single oral dose of 5000 mg/kg
body weight suggests that this is a safe product and has a high antioxidant effect as well as helps
reduce the activity of glucose in the blood. This kind of extract had reduced blood sugar to normal
levels (126.00±16.89 mg/dL, 100% survival) at a dose of 400 mg/kg weight of male white mice. There
was no significant difference with the physiological control mice, which were more effective than those
treated with glucophage (187.2±11.87 mg/dL). This extract also exhibited moderate antioxidant
activities with EC50 value of 80.81 ± 0.91; 93.61 ± 0.31; 106.52 ± 0017; 114.41 ± 1.01 μg/mL
according to ABTS·+, FRAP, RP and DPPH methods, respectively. However, the exception of EC50
values up to 349.31 ± 0.14 μg/mL when using the TAC method.