PHÂN TÍCH CARBOXY - DELTA 9 - THC TRONG MẪU NƯỚC TIỂU BẰNG SẮC KÝ LỎNG KHỐI PHỔ (UPLC-MS/MS)

  • Đặng Đức Khanh
  • Nguyễn Thị Ngọc Minh
  • Phạm Đức Trọng
  • Nguyễn Xuân Trường
Từ khóa: Carboxy-delta 9-THC, THC, LC-MS/MS, urine samples

Tóm tắt

The research reported the results of analysing Carboxy-delta 9-THC in urine samples of drivers using ultraperformance liquid chromatography coupled to a triple quadrupole mass spectrometer (UPLCMS/MS). Concentrations of Carboxy-delta 9-THC in urine samples were varied from 16ng/ml to 185ng/ml. The UPLC-MS/MS operated in multiple reaction monitoring (MRM) mode with positive ionization, analysis resulted in 10 minutes. Sample treatment using solid phase extraction with C18 gave recovery values more than 85%, the relative  repeatability standard deviation value was lower than 10%. The linear of Carboxy-delta 9-THC was tested in range from 10 to 500ng/ml in urine. The limit of detection and limit of quantification of the proceduce were 2,7 and 8,9ng/ml, respectively.

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Phát hành ngày
2021-01-18
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