SYNTHESIS OF SOME o-AMINOPHENOL DERIVATIVES AND ANTIOXIDANT ACTIVITIES

Tóm tắt

o-Amino phenol derivatives are well-known reagents in organic synthesis. Two o-aminophenol 6a, 6b were synthesized successfully from corresponding o-nitrophenol derivatives in 75% over the yield in 5 steps. Two steps were promoted with microwave irradiation for 4-6 minutes in high yield. Conversion of nitro to amino group was reduced with Na₂S₂O₄ in ethanol in 75% yield. Structures of them were elucidated carefully by IR and NMR methods. Two compounds 6a, 6b were exhibited antioxidant activity with SC₅₀ = 12.23 mg/mL and 22.96 mg/mL.