Synthesis under microwave irradiation and cytotoxic activity of some Dibenzo (Perhydrotriazino) ZAA-14-CROWN-4-Ether derivatives

Abstract

Nowadays, many researchers are interested in the development of chemistry of azacrown ethers, especially with the derivatives which contain both periiydrotriazine moiety and crown ether cycle. In some previous publications we have firstly cominunicated about the elaboration of novel method which allowed us to prepare dibenzo(perhydrotriazino)aza-14-crown-4 ether derivatives by condensation reaction of polyether (I) with thiourea or guanidine in the presence of ammonium acetate at room temperature. The yields of these compounds prepared in acetic acid were about 73 %. However, the time of this reaction was rather long (about 13 h) what brings certain limits to possible practical applications of the target compounds. Therefore, for optimising the synthetic method, in this report, we have successfully fulfilled this reaction by using irradiation energy without acetic acid. All the analytical results, physicochemical constants and spectrocospic data showed that all the substances obtained from both used methods are identical same. The biological activities of the prepared (perhydrotriazino)aza-14-crown-4 ether derivatives have been tested.