Study on synthesis and cytotoxic activity of analogue stytyl-lactones

  • Đoàn Thị Mai Hương
  • Phạm Văn Cường
  • Nguyễn Văn Hùng
  • Daniele Bonnet-Delpon
  • Châu Văn Minh

Abstract

The styryl-lactones belong to a group of secondary metabolites commonly isolated from the family Annonaceae. Among them, howiinol A, goniotriol, goniodiol and goniothalamin were demonstrated to have significant antitumour activity against several human tumor cell lines. Recently, we have announced the synthesis and cytotoxic evaluation of howiinol A and some derivatives. In this paper, we report about our continuing attempts to synthesize 6 analogue styryl-lactone. One of them, specially, compound 3 has high activity against KB cancer cell lines with ICso = 0.88 pg/ml. The structure of all compounds were confirmed by spectral methods, including COSY, HSQC, HMBC, NOESY, MS, 19F NMR.

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Published
2017-08-24
Section
Articles