STUDIES ON THE SYNTHESIS OF 4,7-DICHLOROQUINOLINE

Abstract

4,7-dichloroquinoline is a key precursor in the synthesis of the anti-malarial drug amodiquine. The synthesis of this compound from 3-chloroaniline and ethyl ethoxymethylenemalonate was studied using different conditions. The structure of this compound and all intermediates were characterized by NMR and other physico-chemical methods.