Investigation on antibactetial activity of ailphan-mangostin from the fruit hulls of garvinia mangostana L.

Abstract

Mangosteen, Garcinia mangostana Linn (Guttiferae), is imported from Thailand and cultivated in Taiwan. Moreover, the rinds of the fruit have been used as a traditional medicine in Thailand for the treatment of trauma, diarrhea, and skin infections. Mangosteen is a common fruit plant in the South of VietNam. The xanthones, a- mangostin, b- mangostin and g-mangostin, are major bioactive compounds found in the fruit hulls of the mangosteen. The biological activities of a- mangostin have been confirmed to consist of antibacterial activity, anti-inflammatory activities, and antioxidant activity.

The data showed that a- mangostin, isolated from the rinds of fruit Garcinia mangostana L., was found to be active against E. coli DH5a and S. aureus. Minimum inhibitory concentration of --mangostin for S. aureus strains and E. coli DH5a were to 15 mg/ml and 800 mg/ml, respectively. Antibaterial activity of --mangostin inhibited to 80 % the growth for B. subtilis XL62 strain at concentrations of 1000 mg/ml. Meanwhile, α-mangostin only inhibited 70 % for P. aeruginosa DngL1 strain at the same concentration.

Therefore, the above results demonstrate that a- mangostin from the fruit hulls of G. mangostana are antibaterial substances, and can serve as lead compounds in the development of antibaterial drugs.