ISOLATION OF POLYSACCHARIDES FROM HERICIUM ERINACEUS AND THEIR ANTI-TUMOR ACTIVITY
Trần Thị Hồng Hà
Lê Hữu Cường
Trần Thị Như Hằng
Lưu Văn Chính
Lê Mai Hương
Abstract
Polysaccharides from fruiting body of Hericium erinaceus were isolated using hot water and akaline solution and their contents were determined. Polysaccharides extracted with 4 % NaOH were accounted for over 80 % of total polysaccharides and contained both water soluble and insoluble forms. A small amount of polysaccharides was also detected in the cultured medium. The water soluble, NaOH- extracted polysaccharides showed inhibitory activity against tumor forming of Hepatocellular carcinoma cells (Hep-G2) by decline in dimentions of tumors and tumor forming density 24.4 % , 61.5 % respectively, in comparion to no-treated cells (control).