INITIAL SURVEY AND ASSESSMENT OF SOME ANTIBIOTICS IN SURFACE WATER OF THE VAN QUAN LAKE, HANOI

Abstract

Using and releasing antibiotic residues into the environment can affect aquatic ecosystems. This paper presents the observation results of the concentrations of
eight antibiotics, including β-lactam (amoxicillin, AMO), macrolide (azithromycin, AZI), fluoroquinolones (ciprofloxacine, CIP, and ofloxacine, OFL), benzimidazole
(oxfendazole, OXF), lincosamide (lincomycin, LIN), and sulfonamide (sulfaceamide, SCE, and sulfamethoxazole, SME) in the surface water of the Van Quan lake, Hanoi
city, during the period 2022 - 2023 which were simultaneously analyzed with a high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)
method. The research results showed that the total concentrations of 8 antibiotics (Σ8ABX) ranged from 526 - 2240ng/L, with an average value of 1467.3ng/L. Among
the 8 antibiotics surveyed, 3 antibiotics (OXF, AMO, and SCE) were not detected; OFL was detected in all observed samples; and the remaining antibiotics were detected
with a lower frequency. The results of the ecological risk assessment (RQ) showed that OFL, SME, and LIN had moderate to high RQ values for algae, while the RQ values
of OFL and CIP were very high for bacteria. All five detected antibiotics had very low RQ values for invertebrates were found for all five detected antibiotics. High
population density and untreated wastewater can be the cause of antibiotic residues in the lake water. The results contribute to the dataset on antibiotic concentrations
in surface water and also contribute to the scientific basis for providing solutions to protect the water environment in large cities in Asia.