STUDY ON CHEMICAL CONSTITUENTS OF DICHLOROMETHANE FRACTION EXTRACT OF LANTANA CAMARA L. COLLECTED IN THE COASTAL AREAS OF THAI BINH, VIETNAM

Abstract

The n-hexane and dichloromethane extracts of Lantana camara L. collected in the coastal
areas of Thai Binh, Vietnam exhibited cytotoxicity against liver cancer cell lines (Hep-G2) with
the IC50 values of 9.62  0.89 and 14.04  1.38g/mL, respectively. Three compounds
including lantadene B (1), oleanolic acid (2), and pomonic acid (3) were isolated from
dichloromethane extract of this plant. Their structures were determined by modern
spectroscopy methods such as 1D, 2D-NMR and ESI-MS, as well as by comparison with the
data reported in the literature. This is the first time the Hep-G2 cytotoxicity activity of the
fraction extracts of Lantana camara L. have been studied in Vietnam.