NEOLIGNAN VÀ BENZOPHENONE ISOLATED FROM THE Aquilaria sinensis WOODS AND THEIR CYTOTOXIC ACTIVITY

Abstract

Aquilaria sinensis (Lour.) Sprengel, belongs to Thymelaeaceae, a widespread Aquilariaspecies, is cultivated in the Northern mountainous for producing
resinous heartwood, also called agarwood. By combined column chromatography, compounds 1 and 2 were isolated from the n-butanol extract of Aquilaria
sinensis woods grown in Son La province. Their structures were identified as a neolignan, dehydrodiconiferyl alcohol (1) and benzophenone, iriflophenon 2-O-
-rhamnoside (2) by analyzing spectroscopic data, including HR ESI MS, 1D NMR (
1
H-,
13
C NMR, DEPT) and 2D NMR (HSQC, HMBC, COSY, NOESY). For the first
time, the cytotoxic activity of two isolated compounds (1 and 2) was assessed against four human cancer cell lines (KB, HepG2, Lu and MCF7) using the MTT
method to result the significant effect of compound 1 against all four human cancer cell lines with IC50 values ranging from 21.06 to 28.60μg/mL.