Journal of Science, S. 1 (2016)

Cỡ chữ:  Nhỏ  Vừa  Lớn

Hypoglycemic effect of lotus (Nelumbo nucifera gaertn.) Flower ethanolic extract on alloxan induced diabetes rat model

HO THI HUYNH THU, PHAM THI THANH XUAN, NGUYEN THI THUY HANG, NGUYEN NHUT VU, TRINH HUU PHUC

Tóm tắt


    The current study was purposed to evaluate an acute toxicity and effects of lotus (Nulumbonucifera Gaertn.) flower ethanolic extract (LFEE) on alloxan induced diabetic rats. In vivo acutetoxicity study of LFEE was carried out via the guideline of the testing of Chemicals (OECD) byoral administration at limit test of 2000 mg/Kg and 5000 mg/Kg, the results showed that, LD50was greater than the limit dose at 5000 mg/Kg. The various dosages, including 150 and 200mg/Kg, were enrolled in current study to evaluate its effect on fasting blood glucose reduction.The results revealed that LFEE had hypoglycemic activity, no signs and disorder symptoms wereobserved in the period of oral administration. Furthermore, the extract at a dose of 150 mg/Kgshowed the good effect on reducing of fasting blood glucose. These findings indicated that LFEEhad non acute toxicity and hypoglycemic activities, in future, alternative beneficial products in atreatment of diabetes.    

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Journal of Science - Ho Chi Minh City Open University