Laboratory Evaluation of Efficacy of Inactivated Vaccine Using The Canine Distemper CDV-VNUA-768 Strain

Abstract

    Canine distemper inactivated vaccines produced from CDV-VNUA-768 strain virus were evaluated for their protected capacity dogs by inoculating with CDV-HUA-04H strain virus. Six female Beagle dogs (six weeks old) were injected with the vaccine produced from CDV-VNUA-768 strain virus and inoculating with CDV-HUA-04H strain virus after 3 week post injection. Antibody response in dogs after vaccination against Canine distemper virus was examined by ELISA. Antibody contents reached above critical level after 21 days of vaccination and maximum value during 35- 42th day (titer mean of antibody was 1.54) after vaccination. Between from 42th day to 49th day after vaccination, antibody contents decreased but maintained above the critical level at 49th day ( titer mean of 1.35). After 21 day post inoculation with CDV-HUA-04H strain virus, the vaccine groups produced specific antibody for canine distemper virus with titer mean above critical level (0.69). Result of this study showed that dogs were protected with 100 percent when they were injected with inactivated vaccine produced from CDV-VNUA-768.